Cayo Guillermo hotels from

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check Cayo Guillermo hotel prices

Tomorrow night
This weekend
Next weekend

Filter by

Guest rating
Guest rating
Property class

Top 10 trending Cayo Guillermo hotels

Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

What's the best place for a stay in Cayo Guillermo?

Hotel Grand Muthu Cayo Guillermo is one of the top choices for your stay based on our traveller data. This hotel features satellite TV and minibars. Other good options for your visit include Villa Gregorio and Iberostar Daiquirí - All inclusive. See all available top hotels, or vacation rentals in Cayo Guillermo.

If I need to cancel my hotel reservation in Cayo Guillermo, will I receive a refund?

Yes! You'll find that most hotel room reservations are fully refundable provided that you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cayo Guillermo.

What's the best family accommodation in Cayo Guillermo?

Iberostar Daiquirí - All inclusive is a property with 2 outdoor pools and a free children's club, and it's a top choice on Expedia for families. Find more child-friendly accommodations in Cayo Guillermo.

What's the best accommodation for couples in Cayo Guillermo?

Sol Cayo Guillermo - All Inclusive is a favourite property for couples, and features rainfall showerheads and 4 restaurants. Another good option for a stay with your sweetheart is Iberostar Daiquirí - All inclusive. See all romantic hotels in Cayo Guillermo.

What's the best accommodation for an all-inclusive stay in Cayo Guillermo?

Iberostar Daiquirí - All inclusive is an all-inclusive property featuring 3 restaurants and 2 outdoor pools, and a favourite with Expedia travellers. Club Cayo Guillermo - All Inclusive is another good option for your stay. See more all-inclusive resorts in Cayo Guillermo.

What's the best dog-friendly place to stay in Cayo Guillermo?

Sol Cayo Guillermo - All Inclusive is a top property for people travelling with their pets, and offers 4 restaurants and an outdoor pool for its human guests. See more pet-friendly hotel accommodations in Cayo Guillermo.

What's the best accommodation option for a beach holiday in Cayo Guillermo?

Villa Gregorio is a top beachfront hotel with free breakfast and free parking, and it's located close to Cayo Guillermo Beach . Other good choices to stay near the beach include Iberostar Daiquirí - All inclusive and Club Cayo Guillermo - All Inclusive. See more stays near the beach in Cayo Guillermo.

What's the best luxury accommodation option in Cayo Guillermo?

Iberostar Daiquirí is a 4-star property with 3 restaurants and 4 bars, and it's a popular choice for Expedia travellers looking for a pampered stay. Find more luxury hotels in Cayo Guillermo.

What are some hotels with pools in Cayo Guillermo?

Sol Cayo Guillermo - All Inclusive is a top property with a children's pool, an outdoor pool and 4 restaurants. View all hotels with pools in Cayo Guillermo.

What is the best spa hotel in Cayo Guillermo?

Sol Cayo Guillermo - All Inclusive is a top beach spa hotel featuring 4 restaurants, 5 bars, a pool and a fitness centre. Enjoy a massage at the on-site spa. Other popular spa hotels in Cayo Guillermo include Iberostar Daiquirí - All inclusive and Club Cayo Guillermo - All Inclusive. See all spa hotels in Cayo Guillermo.

What's staying in Cayo Guillermo like?

Visitors can enjoy all that Cayo Guillermo has to offer, including the local tours, entertainment choices and beaches. In Cayo Guillermo, there are 4 hotels and other accommodation options to choose from. Find out more about Cayo Guillermo.

What should I do while I'm visiting Cayo Guillermo?

A favourite place to visit is Cayo Guillermo Beach. Additionally, you'll find Parque Natural el Bagá in the area. Take a look at what more there is to see and do in Expedia's Cayo Guillermo guide.

What's the seasonal weather in Cayo Guillermo?

The hottest months are usually August and September, with an average temperature of 28°C, while the coldest months are January and March, with an average of 24°C. Average annual precipitation for Cayo Guillermo is 1143 mm.